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What Is Autism, Really?
A systems view — not a single cause, not a single outcome Lori Hogenkamp | Center for Adaptive Stress Most people are trying to answer the wrong question. They ask “What causes autism?” as if… Read more
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New Research: When Fat Talks to the Brain: A Metabolic Pathway for Stress and Anxiety
For most of medicine, we’ve treated anxiety as something that “lives in the brain.” A feeling from your life or your approach to life that is imagined, real or somatic. An issue you need to… Read more
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The Brass Ring Problem
Eight independent research programs- Cell Danger Response, RCCX Theory, mitochondrial dysfunction, Polyvagal Theory, BH4 pathways, CHD8 chromatin studies, microbiome research, and methylation studies have converged on the same underlying phenomenon from different entry points. he… Read more
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Beyond “Just-So Stories”: The DCIDE Framework and What Comes Next
A welcome advance in evolutionary psychiatry—and an invitation to go further A new paper in Biological Reviews caught my attention this month. Adam Hunt and Adrian Jaeggi, working from the Institute of Evolutionary Medicine at… Read more
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Personality, Pain & the Plinko Board: Rethinking Diagnosis Through the Lens of Neurodevelopment and Stress
Why do two people respond so differently to the same life event, medication, or diagnosis? Why do chronic pain, hormonal shifts, and anxiety so often cluster together — yet look so different from person to… Read more
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All Roads Lead to Stress- Why Stress is the Answer
Why the Architecture of Stress Models are Essential for the Future of Health and Medicine Welcome to the latest insights from the Center for Adaptive Stress, where we delve into the pivotal role of evolutionary… Read more
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Beyond Causation: Reframing Autism Through the Biopsychosocial-Nutritional Model and the Evolutionary Stress Framework
This paper, developed in collaboration with ChatGPT, presents the Biopsychosocial-Nutritional (BPSN) model and the Evolutionary Stress Framework (ESF) as integrated frameworks to understand autism as an emergent neurotype. The authors aim to move beyond genetic… Read more
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Metaphors for Understanding the Impact of the Evolutionary Stress Framework and Emergent Paradigms
*This paper was developed as part of an ongoing two-year collaboration between myself and the AI research assistant ChatGPT, whose contributions span drafting, refinement, conceptual alignment, and literature integration. While I (Lori Hogenkamp) remain the… Read more
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When the Frame Shifts, So Do the Questions: Why Paradigm Matters More Than Position
By Lori Hogenkamp, Center for Adaptive Stress There’s a moment—sometimes subtle, sometimes seismic—when a person no longer just debates different answers, but begins to ask entirely new questions. This is the signature of a paradigm… Read more
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Stress Is Not a Variable—It’s the Framework
By Lori Hogenkamp | Knowledge Architect | Center for Adaptive Stress Why Stress Needs a Reframe Most people think of stress as a variable—something to reduce, manage, or avoid. It’s often framed as a background… Read more
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