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Cancer Through the ESF Lens: Why Architectural Heterogeneity Matters
A complexity-informed perspective on why cancer heterogeneity may reflect not only tumor biology, but differences in host regulatory architecture Most cancer models still center the lesion: what mutation, what carcinogen, what pathway, what exposure. Those… Read more
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Flatland and the Ocean: Why Behavioral Models Break Down at Sea
The New York Times just published a piece called “Short Naps, Long Hours: How Autism Clinics Squeeze Medicaid Dollars Out of Preschoolers” (Ghorayshi, May 23, 2026). It follows months of Wall Street Journal investigations exposing… Read more
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The Emergent Paradigm: Why Medicine Keeps Hitting the Same Wall
A bridge essay on the historical, conceptual, and structural shift toward adaptive medicine Lori Hogenkamp | Center for Adaptive Stress | evostress.blog For years, medicine has looked increasingly uncertain about the conditions affecting the largest… Read more
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Stop Splitting Diagnoses. Start Splitting Medicine.
A companion to: “If We Did Split the Spectrum: What Would It Actually Require?” Lori Hogenkamp | Center for Adaptive Stress | evostress.blog The autism spectrum is fragmenting under the weight of its own heterogeneity.… Read more
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If We Did Split the Spectrum: What Would It Actually Require?
A companion to: “The Autism Spectrum Isn’t Collapsing. The Model Is. We Just Don’t See It Yet.” Lori Hogenkamp | Center for Adaptive Stress | evostress.blog Over the past several months, a growing number of… Read more
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The Architecture Beneath the Spelling Debate
On the Schlosser Review, the Microbiome, and the Question Controlled Trials Can’t Reach Note: Nothing in this argument reduces the importance of protecting nonspeaking individuals from facilitator influence, coercion, projection, or misattributed communication. The neuroscientist… Read more
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The Wrong Fight
Why borrowing systems-medicine vocabulary into pathology logic keeps producing “lite” versions — and what taking the model seriously would require. It’s not the word. It’s the model the word is doing work inside. We’ve been… Read more
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On Lineage: Where “Neurodiversity-Lite” Comes From, and What I’m Adding
A positioning note on the term “neurodiversity-lite,” the lineage of its development, and what the Evolutionary Stress Framework is contributing to an existing conversation. I’ve been writing about “neurodiversity-lite” across the ESF PSA series and… Read more
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The Purse Came Off. The Pathology Stayed
Autistic anxiety. Autistic burnout. Autistic menopause. These may share diagnostic labels with general-population presentations, but they often emerge through different neurological, sensory, interoceptive, and perceptual architectures meeting different conditions. The diagnostic label aggregates across configurations… Read more
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Both Autistic, Different Registers: A Clean Case for the Double Empathy Problem
This is what I want research on autistic communication to take seriously. Not — do autistic people read tone? That’s the wrong question, and it’s been the wrong question for a long time. The right… Read more
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